Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression.
Antiestrogens are designed to antagonize hormone induced proliferation and ERalpha target gene expression in mammary tumor cells.Commonly used drugs such as OH-Tamoxifen and rangers acdc top ICI 182780 (Fulvestrant) block cell cycle progression in G0/G1.Inversely, the effect of cell cycle stage on ER regulated gene expression has not been tested di